Condensation of 4-chlorophenylhydrazine (1) with ethyl pyruvate led to the formation of ethy1 pyruvate 4- chlorophenyl thydrazone (2) Fischer Indolization of (2) gave ethyl 5-chloro-1H-indole-2-carboxylate (3). Vilsmeier-Hacck formylation of (3) gave ethyl 5-chloro-3-formyl-1H-indole-2-carboxylate (4). The reaction of (4) with substituted anilines led to the formation of ethytl 3-(N-aryliminomethyl)-5-chloro-1H-indole-2-carboxylate (5-10). Structures of the new compounds were confirmed by both analytical and spectral data (IR, NMR and MS). Antimicrobial screening was also performed.
Said, M., Ghareb, N., & El-Gendy, A. (2007). SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF ETHYL 3-(N-ARYLIMINOMETHYL)-5-CHLORO-1H-INDOLE-2-CARBOXYLATE. Zagazig Journal of Pharmaceutical Sciences, 16(2), 35-38. doi: 10.21608/zjps.2007.169387
MLA
Mohamed Said; Nagat Ghareb; Adel El-Gendy. "SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF ETHYL 3-(N-ARYLIMINOMETHYL)-5-CHLORO-1H-INDOLE-2-CARBOXYLATE". Zagazig Journal of Pharmaceutical Sciences, 16, 2, 2007, 35-38. doi: 10.21608/zjps.2007.169387
HARVARD
Said, M., Ghareb, N., El-Gendy, A. (2007). 'SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF ETHYL 3-(N-ARYLIMINOMETHYL)-5-CHLORO-1H-INDOLE-2-CARBOXYLATE', Zagazig Journal of Pharmaceutical Sciences, 16(2), pp. 35-38. doi: 10.21608/zjps.2007.169387
VANCOUVER
Said, M., Ghareb, N., El-Gendy, A. SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF ETHYL 3-(N-ARYLIMINOMETHYL)-5-CHLORO-1H-INDOLE-2-CARBOXYLATE. Zagazig Journal of Pharmaceutical Sciences, 2007; 16(2): 35-38. doi: 10.21608/zjps.2007.169387
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