SYNTHESIS OF SOME MALEIMIDE DERIVATIVES VIA REGIO AND STEREOSELECTIVE REDUCTION USING SODIUM BOROHYDRIDE

Document Type : Original Article

Authors

1 Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

2 Institut fur Organic Chemie and Makromolekular Chemie, Heinrich-Hein-Universistät, Dusseldorf Universität,Germany

Abstract

Synthesis of specific maleimide derivatives was performed through the stereospecific use of sodium borohydride. The reduction took place on only one of the carbonyl which is adjacent to the phenylamino group or the alky1 amino group. Our results were confirmed by the presence of the formed hydroxyl group using chromatographic and spectroscopic techniques.

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