The key intermediate, 5-(p-chloropheny1)-1H-pyrazole-3-carboxylic acid hydrazide (3),was used for the synthesis of some new hydrazones 8a-g as well as some five membered heterocyclic derivatives such as pyrazoles 10, 11a,b, 12, pyrrole 13, 1,3,4-Oxadiazole 15, 1,2,4-triazole 17 and 1,3,4-thiadiazole 19. Identification of the new compounds was substantiated by spectral data and elemental analysis .Compound 6f which has a sulfadiazine moiety linked to the pyrazole showed a powerful anti-inflammatory activity than diclofenac sodium.
Abd El-Samii, Z., El-Feky, S., & Osman, N. (2007). SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY OF NOVEL PYRAZOLE DERIVATIVES. Zagazig Journal of Pharmaceutical Sciences, 16(1), 19-28. doi: 10.21608/zjps.2007.169370
MLA
Zakaria Abd El-Samii; Said El-Feky; Nermin Osman. "SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY OF NOVEL PYRAZOLE DERIVATIVES", Zagazig Journal of Pharmaceutical Sciences, 16, 1, 2007, 19-28. doi: 10.21608/zjps.2007.169370
HARVARD
Abd El-Samii, Z., El-Feky, S., Osman, N. (2007). 'SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY OF NOVEL PYRAZOLE DERIVATIVES', Zagazig Journal of Pharmaceutical Sciences, 16(1), pp. 19-28. doi: 10.21608/zjps.2007.169370
VANCOUVER
Abd El-Samii, Z., El-Feky, S., Osman, N. SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY OF NOVEL PYRAZOLE DERIVATIVES. Zagazig Journal of Pharmaceutical Sciences, 2007; 16(1): 19-28. doi: 10.21608/zjps.2007.169370
)
View on SCiNiTO