Document Type : Original Article
Authors
1
Department of Pharmacology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
2
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
3
Department of Pharmacology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
Abstract
The present study was designed to clarify the effects of silymarin, taurine and curcumin on hepatic toxicity in rats. Hepatic toxicity was induced with carbon tetrachloride (25 µl /100gn) I.P. 3 times /weekly for 6 weeks. Rats were treated with silymarin (100 mg/kg), taurine (1 gm/kg) and curcumin (75 mg/kg) for 30 days after induction of hepatic toxicity. Plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phoshatase (ALP), blood glucose, total protein and albumin activities were determined, in addition to histopathological examination. Plasma ALT, AST, ALP and blood glucose activities were increased in CCI, treated rats, in addition to reduction in the level of total protein, albumin and globulin. Histopathological examination showed mono-lobular cirrhosis, represented by fibrous tissue encircling individual hepatic lobules, in addition, the portal triads showed extensive cirrhosis with round cells infiltration. Treatment of cirrhotic rats with taurine, silymarin or curcumin showed a significant reduction in ALT, AST and ALP levels. However the previous mentioned drugs caused a significant increase in the level of total protein, albumin and A/G ratio. Oral treatment of cirrhotic rats with silymarin showed remnants of portal fibrosis. However, liver of curcumin or taurine treated rats were apparently normal. Cirrhotic rats treated with curcumin or taurine showed more pronounced effect on ALT, AST, ALP and proteins than silymarin.
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