PREPARATION AND CHARACTERIZATION OF DERMAL FILMS CONTAINING AN ANTI- INFLAMMATORY DRUG

Document Type : Original Article

Authors

1 Department of Pharmaceutics and Industrial Pharmacy. Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, Egypt

2 Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Assiut branch, Assiut, Egypt.

Abstract

Piroxicam is a potent nonsteroidal anti-inflammatory drug associated with many side effects when taken orally. An attention was paid in this work to formulate and characterize piroxicam containing polymer films for dermal use. The used polymers were cellulose types namely ethylcellulos (EC) and hydroxypropy1 methylcellulos (HPMC). In this study, medicated films consısting of drug and carrier were prepared The carrier consisted of one or two polymers The physicochemical characterization was done by IR spectroscopy, DSC and X-Ray diffractometry for both piroxicam polymeric films and their corresponding physical mixtures as well as the untreated drug and polymer powders to investigate the drug polymer interaction The results showed absence of molecular interactions between piroxicam and both EC and HPMC. In-vitro drug release from these polymer films was studied It is found that when the ratio of HPMC increased the drug release from the film become faster

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