AQUEOUS EXTRACT OF HIBISCUS SABDARIFFA ALONE OR IN COMBINATION WITH VALSARTAN ATTENUATES RENOVASCULAR HYPERTENSION IN RATS

Document Type : Original Article

Authors

1 Department of Pharmacology, Faculty of Pharmacy, Zagazig University, Egypt

2 Nuclear Materials Authority, Cairo, Egypt

Abstract

The present study was designed to investigate the possible modulative effects of aqueous extract of Hibiscus sabdariffa (HS) either alone or in combination with valsartan on hypertensive male albino rats. Renovascular bypertension was induced by ligation of left renal artery for 4 weeks. HS in a dose of 250 mg/kg, valsartan in a dose of 5 mg/kg and their combination were given daily to hypertensive rats for 45 days as single oral daily dose. HS either alone or in combination with valsartan reduced blood pressure (BP) and heart rate of hypertensive rats. It also increased aortic glutathione content (GSH) and super oxide dismutase (SOD) activity. It improved lipid profile, decreased nitric oxide (NO) levels and improved the histopathological changes of aorta. Valsartan alone decreased BP more than HS, increased aortic GSH content, aortic SOD activity and NO serum level but failed to correct lipid profile. Based on this study, it can be concluded that HS alone and in combination with valsartan showed potent antihypertensive effects. This effect may be mediated via antioxidant, hypolipidemic effects and correction of lowered serum NO levels. Valsartan has more potent antihypertensive effect than HS but it was not able to correct dyslipidemia and histopathological changes associated with hypertension.

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