QUANTITATIVE ANALYSIS OF SOME PHARMACEUTICAL FORMULATIONS THROUGH CHARGE TRANSFERCOMPLEXATION REACTION

Document Type : Original Article

Authors

1 Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University. Zagazig. Egypt.

2 Analytical Chemistry Department , Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.

Abstract

Three accurate, rapid and simple spectrophotometric procedures were developed for the analysis of Aripirazole (I),Sumatriptan succinate (II) Lamivuidine (III) and Rabeprazole sodium (IV) in pure form as well as in their pharmaceutical formulation. The methods were based on formation of charge transfer complexes between the studied drugs as n-electron donors with three different reagents acting as electron acceptor either π-acceptor such as p-chloranilic acid (PCA) and 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) or σ-acceptor as iodine. The different experimental parameters affecting the development and stability of the color including reagent concentration, reaction solvent, time and temperature, were carefully studied and optimized. The obtained charge transfer complexes (CTC) were measured generally at 520nm (for PCA), 460nm (for DDQ) and 290nm (for iodine). Beer's law limits, molar absorbitivity, Sandell's sensitivity, detection and quantifications limits were also investigated The proposed methods were validated and successfully applied for determination of the studied drugs in pure form and in pharmaceutical preparations The obtained results were statistically compared with reference methods and no significant differences were found.

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