Spectrophotometric determination of ranitidine hydrochloride and famotidine using 1,2- naphthoquinone-4-sulphonate.

Document Type : Original Article

Authors

1 Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

2 Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazige University, Zagazig, Egypt

Abstract

Accurate, simple and sensitive spectrophotometric method was developed for the determination of ranitidine hydrochloride and famotidine in bulk and pharmaceutical dosage forms. The method was based on the reaction of these drugs with 1,2-naphthoquinone-4sulphonate in alkaline medium, producing colored products measured atʎmax  488nm and 468 nm for ranitidine HCI and famotidine, respectively . Beer’s law was obeyed in the concentration range from (24-120 µg ml -1) for ranitidine HCI and (6-20 µg ml -1) for famotidine with molar absorpitivity 1.498 x 103 Lmol-1 cm -1and 1.441 x 104Lmol-1 cm-1 respectively. The proposed method was successfully applied for the determination of ranitidine HCI and famotidine in their dosage forms with good accuracy and precisions.

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